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Case Study: Polypharmacology Approaches in Drug Discovery

Symmetry's Global Mechanism of Action (GMoA) model provides decision support in the multi-target approach to deliberately combine in a single molecule scaffolds related to different therapeutic targets. This case study is performed with molecules reported in a recent paper describing the first compound exhibiting gamma-Secretase modulation, PPARgamma agonism and 5-LOX inhibition for the potential treatment of Alzheimer’s disease.


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