In response to the changing and challenging environment for procuring more effective and safer drugs, Prous Institute is developing its Epistemic Drug Discovery® project, based on the application of SYMMETRY and the experimental evaluation of working hypotheses using in vitro assays and in vivo animal models. The project aims to speed up the process of drug discovery and development, reducing time-cost and attrition rate. The process involves the 10 steps below:

Ten Steps to Epistemic Drug Discovery

1. Identify a therapeutic need.

2. Clearly understand the area of drug therapy to be investigated.

3. Construct large libraries of compounds related to the area to be investigated (PSMEL®), including those with reported preclinical data (training sets) and those generated by our IGSME® (In silico Generation of Small Molecular Entities) process.

4. Design new bioactive compounds based on rational approaches to drug discovery, and generate a library with those compounds to be subsequently incorporated into the central library mentioned in point 3.

5. Check patentability of designed compounds.

6. Virtually screen compounds in the libraries using our proprietary cheminformatics tools (SYMMETRY). Each compound is predicted to interact with one or more targets or pathways, produce more than one therapeutic outcome, and have an ADMET profile.

7. Select and synthesize the most promising compounds from the in silico studies.

8. Prepare preclinical itineraries for validating the results from predictive studies and translate them to promising targeted therapies.

9. Estimate the compound's market value based on efficacy, safety and differentiation from more advanced drugs in the same class or drugs with similar indications in a different class of mechanism.

10. File IND (Investigational New Drug) application and initiate phase I clinical studies. 

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