News & Publications

NEWS & PUBLICATIONS

Learn more about Prous Institute and our progress in drug discovery, technology, industry partnerships, collaborations and scientific articles.

25 Latest Articles
Computational Analysis for Hepatic Safety Signals of Constituents Present in Botanical Extracts Widely Used by Women in the United States for Treatment of Menopausal Symptoms
2010 Oct 07

Authors: Wang YJ, Dou J, Cross KP, Valerio LG Jr.  Journal: Regul Toxicol Pharmacol. 2011 Feb;59(1):111-24. Source:  Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Link to Article

Category: Publications, Toxicology, BioEpisteme
Prediction of Drug-Related Cardiac Adverse Effects in Humans--A: Creation of a Database of Effects and Identification of Factors Affecting their Occurrence.
2010 Apr 01

Authors: Matthews EJ, Frid AA. Journal: Regul Toxicol Pharmacol. 2010 Apr;56(3):247-75., PMID: 19932726 Link to Article

Category: Publications, Toxicology, BioEpisteme
Prediction of Drug-Related Cardiac Adverse Effects in Humans--B: Use of QSAR Programs for Early Detection of Drug-Induced Cardiac Toxicities
2010 Apr 01

Authors: Frid AA, Matthews EJ Journal: Regul Toxicol Pharmacol. 2010 Apr;56(3):276-89., PMID: 19941924 Link to Article

Category: Publications, Toxicology, BioEpisteme
Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents.
2008 Aug 01

Authors: Edwin J. Matthews;  Naomi L. Kruhlak;  R. Daniel Benz;  Joseph F. Contrera;  Carol A. Marchant; Chihae Yang. Journal: Toxicol Mech Methods. 2008;18(2-3):189-206., PMID: 20020914 Link to Article

Category: Publications, Technology, Toxicology, BioEpisteme
Comparative Evaluation of hERG Potassium Channel Blockade by Antipsychotics
2007 Sep 01

Authors: Silvestre JS, Prous JR. Journal: Methods Find Exp Clin Pharmacol. 2007 Sep; 29(7):457-65.PMID: 17982510 Link to Article

Category: Publications, Toxicology, BioEpisteme
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