News & Publications

NEWS & PUBLICATIONS

Learn more about Prous Institute and our progress in drug discovery, technology, industry partnerships, collaborations and scientific articles.


Symmetry's Global Mechanism of Action (GMoA) model provides decision support in the multi-target approach to deliberately combine in a single molecule scaffolds related to different therapeutic targets. This case study is performed with molecules reported in a recent paper describing the first compound exhibiting gamma-Secretase modulation, PPARgamma agonism and 5-LOX inhibition for the potential ...


Prous Insitute is pleased to announce the launch of our new website showcasing the features and benefits of Symmetry, the world’s first integrated predictive platform for drug discovery and safety evaluation.  To visit the website please click here.   


Symmetry's Global Mechanism of Action (GMoA) model helps anticipate potential off-target safety liabilities of new structures early in drug discovery. This case study is performed with molecules reported in a recent paper describing the optimization of compounds for the potential treatment of Alzheimer ’s disease, minimizing cardiovascular liabilities (hERG channel blockade). To recei...


A new paper co-authored by scientists at US FDA and Prous Institute for Biomedical Research describes the development and validation of a QSAR model to predict Salmonella t. mutagenicity (Ames assay outcome) of pharmaceutical impurities using Prous Institute SYMMETRY SM, the world’s first integrated in silico solution for drug discovery and safety screening.  Data was sourced from publi...


A new paper published by US FDA scientists (In silico modeling to predict drug-induced phospholipidosis; Sydney S. Choi, Jae S. Kim, Luis G. Valerio Jr., Nakissa Sadrieh;  Toxicol Appl Pharmacol. 269 (2013) 195–204) explores the use of Prous Institute’s SYMMETRY® in the construction and validation of QSAR models for the identification of drug-induced phospholipidosis (DIPL). T...

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