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Learn more about Prous Institute and our progress in drug discovery, technology, industry partnerships, collaborations and scientific articles.

Part C: use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities.  Describes the regulatory use of BioEpisteme and other predictive systems. Authors: Matthews EJ, Kruhlak NL, Benz RD, Aragonés Sabaté D, Marchant CA, Contrera JF. Journal: Regul Toxicol Pharmacol. 2009 Jun;54(1):43-65, PMID: 19422...

Authors: Wang YJ, Dou J, Cross KP, Valerio LG Jr.  Journal: Regul Toxicol Pharmacol. 2011 Feb;59(1):111-24. Source:  Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA. Link to Article

Authors: Matthews EJ, Frid AA. Journal: Regul Toxicol Pharmacol. 2010 Apr;56(3):247-75., PMID: 19932726 Link to Article

Authors: Frid AA, Matthews EJ Journal: Regul Toxicol Pharmacol. 2010 Apr;56(3):276-89., PMID: 19941924 Link to Article

Authors: Edwin J. Matthews;  Naomi L. Kruhlak;  R. Daniel Benz;  Joseph F. Contrera;  Carol A. Marchant; Chihae Yang. Journal: Toxicol Mech Methods. 2008;18(2-3):189-206., PMID: 20020914 Link to Article

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