SYMMETRY®, an ensemble of computational tools and methods, aims to replicate all the processes through which new drugs are discovered, developed and approved in a conventional laboratory. Drug repositioning has emerged as a useful strategy to overcome the challenge of decreasing productivity in drug R&D. SYMMETRY® provides a wide variety of innovative approaches to drug repositioning, as will be illustrated in a series of case studies to be presented starting February 2012, as webcasts and articles:

1.     New Target Discovery for Natural Products: Discovery of SGLT2 Inhibitors from Anti-diabetic Medicinal Plants

2.     Discovery and Design of Multi-targeted Agents from Medicinal Plants

3.     New Indication Discovery from Gene Expression Signatures

4.     New Mechanisms of Action and Indication Discovery using Adverse Effect Similarity

5.     New Indication Discovery for Clinical Candidates that have been Discontinued for Non-Safety Reasons

6.     Repositioning Strategies for Commercially Available Compounds

7.     Beyond Current Drug Repositioning (Part 1): Maximizing the Added Value of Patents (Extending a Drug's Patent Life)

8.     Beyond Current Drug Repositioning (Part 2): Maximizing the Added Value of Scientific Articles

Please contact us for more information about our Spotlight features.