STER® : Prediction of Toxic/Adverse Effects
STER® establishes the probability of small molecular entities (SMEs) interacting with a target or multiple targets to produce a toxic outcome. STER® includes several models for predicting adverse effects and toxicity profiles of SMEs. These models aim to restrict animal usage to situations in which it is absolutely necessary and reduce attrition rates. STER® is complementary to SADMER® and SMAR®. Virtual screenings with STER® are complemented by experimental studies to validate the mechanisms underlying the adverse effects of SMEs (1).
Applications
- Prediction of adverse reactions and toxic effects based on molecular mechanisms of action.
- Drug target identification using side effect similarity.
- Construction of molecular scenarios to decipher the toxic effects of molecular entities and their metabolites.