At Prous Institute we define Epistemic Drug Discovery®  (EDD) as a holistic, knowledge based and proactive approach to drug discovery designed to: develop structure-based models for the prediction of drug efficacy and safety; generate and validate hypotheses through synthesis, in vitro and in vivo pharmacological testing and pharmacogenetic studies. Two pillars uphold EDD: bioinformatics/chemoinformatics and basic research, leading to new bioactive compounds.