(1) Research on Adverse Drug Events. I. Muscarinic M3 Receptor Binding Affinity Could Predict the Risk of Antipsychotics to Induce Type 2 Diabetes. Silvestre JS, Prous J. Methods Find Exp Clin Pharmacol. 2005 Jun;27(5):289-304.
(2) Toxicological and Clinical Computational Analysis by the Informatics and Computational Safety Analysis Staff of the US FDA/CDER. Daniel R. Benz, Edwin J. Matthews, Naomi L. Kruhlak, Anna A. Frid, Barbara L. Minnier and Joseph F. Contrera. AATEX 14, Special Issue, 463-467, Proc. 6th World Congress on Alternatives & Animal Use in the Life Sciences, August 21-25, 2007, Tokyo, Japan.
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Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents. Edwin J. Matthews; Naomi L. Kruhlak; R. Daniel Benz; Joseph F. Contrera; Carol A. Marchant; Chihae Yang. Toxicology Mechanisms and Methods, Volume 18, Issue 2 & 3 February 2008, pages 189 - 206 ...view article abstract
(6) Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities. Matthews EJ, Kruhlak NL, Benz RD, Aragonés Sabaté D, Marchant CA, Contrera JF.Regul Toxicol Pharmacol. 2009 Jun;54(1):43-65