Next-Generation Drug R&D Force

The changing and challenging environment for procuring more effective and safer drugs has encouraged Prous Institute to develop the Epistemic Drug Discovery® (EDD) project,  based on the in silico generation of working hypotheses and the experimental evaluation of their validity using in vitro assays and in vivo animal models. The project aims to speed up the process of drug discovery and development, reducing the time-cost and attrition rate.

 

 

 Targeting Value Creation Zones
 
Based on structure-activity relationships, a series of mathematical models of computation (BioEpisteme®) are being developed to predict potential mechanisms of action, therapeutic activities, toxicities, ADME profiles, drug interactions and the role in cellular processes of small molecular entities. These predictive models are integrated in an in silico Drug Discovery System (i-DDS), which orbits the unlimited chemical and biological spaces (PSMEL® and Conveyor® respectively), identifying dynamic interplays which, through experimentation, lead to potential therapeutic candidates.
  
 
 The Natural Way to Drug Discovery
 
 
Natural products are attractive sources for discovering new drugs. The mechanisms of action of thousands of molecular entities from medicinal plants remain to be elucidated. Experimental screening of these compounds is time-consuming and costly. Computational structure-based tools developed at Prous Institute allow rapid, reliable and cost-effective screening of compounds with a vast molecular diversity against therapeutic targets for diabetes, stress-related psychiatric disorders,  chronic obstructive pulmonary disease (COPD)  and chronic asthma.                          more...
 
 Strategies for Autophagy Modulation
 
 
Prous Institute has initiated a research program focused on the discovery of new small-molecule modulators of autophagy as therapeutic agents. Autophagy is an important topic in modern cell biology. It is implicated in a variety of diseases, including cancer, neurodegenerative diseases, muscular disorders and viral and bacterial infections. The number of publications related to autophagy is growing exponentially.                                             more...

  

  
July 22, 2010:   Prous Institute Presents Its Progress at IUTOX 2010
 
July 19, 2010:  Prous Institute is Gold Sponsor of the 2010 IUTOX Meeting more...
  
April 20, 2010: 2010 Prous Institute - Overton and Meyer Award   more...
     

Epistemic Drug Discovery 

  
A large computational project with basic research support and broad disease coverage is bringing Prous Institute closer to drug discovery.            more...

 

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